I am relatively new on this site and I am enjoying reading and learning as much as I can. I was diagnosed in 2008 and retired last year. Soon after my last appointment with my endo I started having odd problems with my blood glucose usually running high and sometimes unexpectedly dropping low. I know that my pump is working and that insulin is getting through the tubing and cannula. I have been on the phone with my endocrinologists’ office and will see her next week. I have been diagnosed (recently) with EPI and I am also on antibiotics for an infection. Since my BG problem started before starting the enzymes for EPI and the antibiotics for the infection.
I know that my endo will review my pump settings. Unless something else is learned I have been told that my endo is considering the addition of another medication and/or moving me from U-100 onto U-500 insulin. I suspect that my insulin will be increased unless another cause is found. I currently use 300 units every 1.5 – 1.75 days or a vial every 5-6 days.
I am looking for information and/or studies about any possible causes of hyperglycemia other than an incorrect bolus, incorrect bolus timing, dehydration, or an infection. Has anyone else had anything similar or have any ideas or suggestions? I thought that I would try to learn as much as possible before meeting with my endocrinologist. I want to get as much as possible out of my next appointment.
On a side note I was looking for more information about hyperglycemia when I found an interesting study comparing 90-degree insets versus 30-degree insets titled “In vivo investigation of the tissue response to commercial Teflon insulin infusion sets in large swine for 14 days: the effect of angle of insertion on tissue histology and insulin spread within the subcutaneous tissue” at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904176/pdf/bmjdrc-2019-000881.pdf. After reading this study and observing the data showing the pressure differences along with the “…acute inflammatory response…” from cannula insertion into the body. I plan to ask my endo about trying different inset angles while I’m in the office.