I'll include my concluding statements and provide the references I included in my paper as well, in case anyone is interested...
"The study done in Japan also bases its rationale on genetic information, but further focuses its application to T-helper cell involvement. As aforementioned, this study done by Shimada et. al. supported the exaggerated role of interferon-gamma in genetically predisposed T1DM patients. Another study conducted in Chile by Garcia et. al. also identified this same vitamin D receptor polymorphism, BsmI, to be related to T1DM incidence in their study as well6. This finding further supports the proposed exaggerated T-helper cellular response mechanism. Since a T-helper cellular response could be invoked by a viral infection or an environmental factor like an immunization triggering an immune reaction to form antibodies, vitamin D status is further supported as a pervading factor in T1DM risk. Since those with familial history or otherwise known genetic predisposition would be very liable to vitamin D deficiency based on the previously mentioned genetic studies completed in Germany, Japan, and Chile, supplementation of vitamin D and frequent exposure to UVB should be considered to decrease risk of T1DM diagnosis. Further studies are required for researchers to understand the precise involvement of vitamin D and vitamin D receptors in T1DM’s etiology, but the studies published to date do indicate with sufficiency that there is a very strong relationship between the two."
1. Shimada A, Kanazawa Y, Motohashi Y, et al. Evidence for association between vitamin D receptor BsmI polymorphism and type 1 diabetes in Japanese. Journal of Autoimmunity. 2008 Jun;30(4):207-11.
2. Littorin B, Blom P, Scholin A, et al. Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects: results from the nationwide Diabetes Incidence Study in Sweden (DISS). Diabetologia. 2006 Dec;49(12):2847-52.
3. Hypponen E, Laara E, Reunanene A, Jarvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet. 2001 Nov;358(9292):1500-3.
4. Mohr SB, Garland CF, Gorham ED, Garland FC. The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide. Diabetologia. 2008 Aug;51(8):1391-8.
5. Ramos-Lopez E, Brueck P, Jansen T, Herwig J, Badenhoop K. CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibitity to type 1 diabetes and vitamin D levels in Germans. Diabetes-Metabolism Research and Reviews. 2007 Nov;23(8):631-6.
6. Garcia D, Angel B, Carrasco E, Albala C, Santos JL, Perez-Bravo F. VDR polymorphisms influence the immune response in type 1 diabetic children from Santiago, Chile. Diabetes Research and Clinical Practice. 2007 Jul;77(1):134-40.